This ABC Primetime segment aired during the week before the 2007 movie was released. It features clips from the film, along with brief interviews with author Robert Graysmith as well as actor Jake Gyllenhaal. The segment goes on to explore whether the murders can ever be solved.

On October 22th, 1969, a man claiming to be the Zodiac killer calls lawyer Melvin Belli on a KGO-TV morning talk show. News anchor Walter Cronkite introduces the story. Belli was supposed to meet the killer later in the day, but he never showed up. During the call the killer says that he has headaches that started when he killed a kid. Do you think it's real? Is the caller a fake, or is it all a hoax?

Watch various news clips from September/October 1969. The most notable piece of footage is an interview with victim Bryan Hartnell, who was gravely injured during an attack at Lake Berryessa in Napa Valley when the Zodiac took the life of his female companion Cecelia Shepard. Sergeant William White and Chief of Inspectors Martin Lee are also featured.

Harry Smith of CBS News interviews Jake Gyllenhaal about the movie Zodiac. They reveal that the director of the film, David Fincher, grew up in the area at the time of the killings and remembers police cars following his bus to school after the killer threatened to shoot school children getting off the bus.

Author Robert Graysmith and his onscreen counterpart Jake Gyllenhaal talk about the movie and Gyllenhaal's portrayal. Graysmith says that he didn't know that he was obsessed until Gyllenhaal portrayed him. The interviewer questions whether people will be yearning for more of a resolution at the end of the film.

A serial killer in the San Francisco Bay Area taunts police with his letters and cryptic messages. We follow the investigators and reporters in this lightly fictionalized account of the true 1970's case as they search for the murderer, becoming obsessed with the case.